Low doses of nitroparacetamol or dexketoprofen trometamol enhance fentanyl antinociceptive activity.

@article{Gaitn2003LowDO,
  title={Low doses of nitroparacetamol or dexketoprofen trometamol enhance fentanyl antinociceptive activity.},
  author={Gema Gait{\'a}n and Piero del Soldato and Juan Fernando Herrero},
  journal={European journal of pharmacology},
  year={2003},
  volume={481 2-3},
  pages={181-8}
}
We have reported that subeffective doses of the nonsteroidal anti-inflammatory drug (NSAID) dexketoprofen trometamol enhances micro-opioid receptor agonist fentanyl antinociception. The aim of this study was to assess if this effect can also be observed with other new cyclooxygenase-inhibitors such as nitroparacetamol, and in responses to high intensity electrical stimulation (wind-up). Single motor units were recorded in male Wistar rats under alpha-chloralose anaesthesia. The antinociceptive… CONTINUE READING