Low doses of interleukin-1β improve the leverpress avoidance performance of Sprague–Dawley rats

@article{Brennan2003LowDO,
  title={Low doses of interleukin-1β improve the leverpress avoidance performance of Sprague–Dawley rats},
  author={Francis X. Brennan and Kevin D. Beck and Richard J. Servatius},
  journal={Neurobiology of Learning and Memory},
  year={2003},
  volume={80},
  pages={168-171}
}
Recent research has indicated that the pro-inflammatory cytokines, particularly interleukin-1beta (IL-1beta), can affect learning and memory. We injected male Sprague-Dawley rats with IL-1beta (1.0, 3.0, or 6.0 microg/kg, i.p.) or saline vehicle, 24h before a single 4-h session of leverpress escape/avoidance conditioning. No effect of IL-1beta at any dose was observed in the number of escape responses across the 4-h session. However, subjects treated with the two lower doses (1.0 and 3.0 microg… CONTINUE READING
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