Low doses of bone morphogenetic protein 4 increase the survival of human adipose-derived stem cells maintaining their stemness and multipotency.

@article{Lpez2011LowDO,
  title={Low doses of bone morphogenetic protein 4 increase the survival of human adipose-derived stem cells maintaining their stemness and multipotency.},
  author={Mar{\'i}a A Vicente L{\'o}pez and Miriam Nohem{\'i} V{\'a}zquez Garc{\'i}a and Ana Entrena and Susana Olmedillas L{\'o}pez and Mariano Garc{\'i}a-Arranz and Dami{\'a}n Garc{\'i}a-Olmo and Agust{\'i}n Zapata},
  journal={Stem cells and development},
  year={2011},
  volume={20 6},
  pages={1011-9}
}
Mesenchymal stem cells (MSCs) have emerged as important tools for cell therapy; therefore, identification of factors capable of governing their ex vivo expansion become essential. In this study we demonstrate that human adipose-derived stem cells (ASCs) express all components of the bone morphogenetic protein (BMP)/BMP receptor signaling pathway and respond to BMP4 inducing upregulated expression of its specific target genes Id1-Id4. Moreover, ASCs grown in a medium reduced in serum produce… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Similar Papers

Loading similar papers…