Low doses of CMV induce autoimmune-mediated and inflammatory responses in bile duct epithelia of regulatory T cell-depleted neonatal mice

@article{Wen2015LowDO,
  title={Low doses of CMV induce autoimmune-mediated and inflammatory responses in bile duct epithelia of regulatory T cell-depleted neonatal mice},
  author={J. Wen and Yongtao Xiao and J. Wang and Weihua Pan and Ying Zhou and X. Zhang and W. Guan and Yingwei Chen and Kejun Zhou and Y. Wang and Bisheng Shi and X. Zhou and Z. Yuan and Wei Cai},
  journal={Laboratory Investigation},
  year={2015},
  volume={95},
  pages={180-192}
}
  • J. Wen, Yongtao Xiao, +11 authors Wei Cai
  • Published 2015
  • Biology, Medicine
  • Laboratory Investigation
  • Recent studies have indicated that perinatal infection with cytomegalovirus (CMV) may promote bile duct damage in biliary atresia (BA) and that the decreased regulatory T cell (Treg) percentage associated with BA may further amplify the bile duct damage. Although a majority of BA patients have had previous CMV infections and lower percentages of Tregs, it is unknown whether an initial exposure to a low dose of CMV could induce exaggerated and progressive biliary injury. A Treg-depleted neonatal… CONTINUE READING
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