Low-dose vemurafenib induces complete remission in a case of hairy-cell leukemia with a V600E mutation.

@article{Peyrade2013LowdoseVI,
  title={Low-dose vemurafenib induces complete remission in a case of hairy-cell leukemia with a V600E mutation.},
  author={Fr{\'e}d{\'e}ric Peyrade and Daniel Re and Cl{\'e}mence Ginet and Lauris Gastaud and Maryline All{\'e}gra and Robert Ballotti and Antoine Thyss and Thorsten Zenz and Patrick Auberger and Guillaume Robert},
  journal={Haematologica},
  year={2013},
  volume={98 2},
  pages={e20-2}
}
Hairy-cell leukemia (HCL) is a lymphoproliferative disorder characterized by the presence of CD103-positive circulating B cells, pancytopenia and splenomegaly. HCL cases were recently shown to harbor a mutation at codon 600 of BRAF (V600E), suggesting that this genetic event represents a key driver of the disease. Recently, Dietrich et al. reported a case of refractory HCL treated with escalating doses of vemurafenib. Vemurafenib exhibited remarkable activity, with rapidly decreased… CONTINUE READING

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