Low-dose total body irradiation (TBI) and fludarabine followed by hematopoietic cell transplantation (HCT) from HLA-matched or mismatched unrelated donors and postgrafting immunosuppression with cyclosporine and mycophenolate mofetil (MMF) can induce durable complete chimerism and sustained remissio

@article{Niederwieser2003LowdoseTB,
  title={Low-dose total body irradiation (TBI) and fludarabine followed by hematopoietic cell transplantation (HCT) from HLA-matched or mismatched unrelated donors and postgrafting immunosuppression with cyclosporine and mycophenolate mofetil (MMF) can induce durable complete chimerism and sustained remissio},
  author={Dietger Niederwieser and Michael Maris and Judith A Shizuru and Effie W. Petersdorf and Ute Hegenbart and Brenda M Sandmaier and David G Maloney and Barry E Storer and Thoralf Lange and Thomas R Chauncey and Michael Deininger and Wolfram P{\"o}nisch and Claudio Anasetti and Ann E. Woolfrey and M G Little and Karl G. Blume and Peter A. Mcsweeney and Rainer F Storb},
  journal={Blood},
  year={2003},
  volume={101 4},
  pages={1620-9}
}
Toxicities of high-dose conditioning regimens have limited the use of conventional unrelated donor hematopoietic cell transplantation (HCT) to younger, medically fit patients. Based on preclinical studies, an HCT approach has been developed for elderly or medically infirm patients with HLA-matched or mismatched unrelated donors. In this study, 52 patients with hematological diseases were included. Most (88%) had preceding unsuccessful conventional HCT or refractory/advanced disease. Patients… CONTINUE READING
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