Low-dose terlipressin improves systemic and splanchnic hemodynamics in fluid-challenged endotoxic rats.

@article{Asfar2003LowdoseTI,
  title={Low-dose terlipressin improves systemic and splanchnic hemodynamics in fluid-challenged endotoxic rats.},
  author={Pierre Asfar and Marc Pierrot and Nary Veal and Fr{\'e}d{\'e}ric Moal and Fr{\'e}d{\'e}ric Oberti and Vincent Croquet and Olivier Douay and Yves Gallois and Jean-Louis Saumet and Philippe Alquier and Paul Cal{\`e}s},
  journal={Critical care medicine},
  year={2003},
  volume={31 1},
  pages={
          215-20
        }
}
OBJECTIVE Vasopressin has been used to treat arterial hypotension associated with hyperdynamic vasoplegic states, but detrimental effects on splanchnic circulation have been reported. We tested the effects of a low-dose vasopressin analogue, terlipressin (6 microg/kg), on systemic and splanchnic hemodynamics in fluid-challenged endotoxic rats (lipopolysaccharide, 30 mg/kg in 1 hr). DESIGN Prospective, randomized, controlled experimental study with repeated measures. SETTING Investigational… CONTINUE READING

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