Low dose tPA plus annexin A2 combination attenuates tPA delayed treatment-associated hemorrhage and improves recovery in rat embolic focal stroke.

@article{Jiang2015LowDT,
  title={Low dose tPA plus annexin A2 combination attenuates tPA delayed treatment-associated hemorrhage and improves recovery in rat embolic focal stroke.},
  author={Yinghua Jiang and Xiang Fan and Zhanyang Yu and Chongjie Cheng and Xiao-shu Wang and Eng H. Lo and Xiaochuan Sun and Xiaoying Wang},
  journal={Neuroscience letters},
  year={2015},
  volume={602},
  pages={73-8}
}
We previously have shown that tissue type plasminogen activator (tPA) in combination with its receptor annexin A2 (rA2) protein significantly improved tPA thrombolytic efficacy. In this study we aimed to examine the therapeutic effects of the combination when treated at delayed 4-hour window after stroke compared to standard conventional tPA alone in an… CONTINUE READING