Low dose subcutaneous adrenaline to prevent acute adverse reactions to antivenom serum in people bitten by snakes: randomised, placebo controlled trial.

@article{Premawardhena1999LowDS,
  title={Low dose subcutaneous adrenaline to prevent acute adverse reactions to antivenom serum in people bitten by snakes: randomised, placebo controlled trial.},
  author={Anuja P Premawardhena and Chaminda De Silva and Malini Fonseka and Saman B. Gunatilake and Hithanadura Janaka de Silva},
  journal={BMJ},
  year={1999},
  volume={318 7190},
  pages={1041-3}
}
OBJECTIVE To assess the efficacy and safety of low dose adrenaline injected subcutaneously to prevent acute adverse reactions to polyspecific antivenom serum in patients admitted to hospital after snake bite. DESIGN Prospective, double blind, randomised, placebo controlled trial. SETTING District general hospital in Sri Lanka. SUBJECTS 105 patients with signs of envenomation after snake bite, randomised to receive either adrenaline (cases) or placebo (controls) immediately before infusion… CONTINUE READING