Low-dose spironolactone in the management of resistant hypertension: a surveillance study.

@article{Lane2007LowdoseSI,
  title={Low-dose spironolactone in the management of resistant hypertension: a surveillance study.},
  author={Deirdre A Lane and Sarah Zainal Abidin Shah and David John Beevers},
  journal={Journal of hypertension},
  year={2007},
  volume={25 4},
  pages={
          891-4
        }
}
METHODS We have conducted an open observational study of the use of spironolactone 25-50 mg in the management of patients with resistant hypertension. This drug was recommended in 133 patients who were already receiving an angiotensin-blocking drug in addition to other therapies. RESULTS Of these, three defaulted from follow-up and 11 could not tolerate spironolactone. We therefore have outcome data on 119 patients. The addition of spironolactone (median dose 25 mg) was associated with a mean… CONTINUE READING
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