Low-dose sodium nitrite vasodilates hypoxic human pulmonary vasculature by a means that is not dependent on a simultaneous elevation in plasma nitrite.

@article{Ingram2010LowdoseSN,
  title={Low-dose sodium nitrite vasodilates hypoxic human pulmonary vasculature by a means that is not dependent on a simultaneous elevation in plasma nitrite.},
  author={Thomas E Ingram and Andrew G. Pinder and Damian Miles Bailey and Alan G Fraser and Philip E. James},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2010},
  volume={298 2},
  pages={H331-9}
}
Inorganic nitrite has recently been recognized to possess vascular activity that is enhanced in hypoxia. This has been demonstrated in humans in the forearm vascular bed. In animal models nitrite reduces pulmonary vascular resistance, but its effects upon the pulmonary circulation of humans have not yet been demonstrated. This paradigm is of particular… CONTINUE READING