Low dose rotenone treatment causes selective transcriptional activation of cell death related pathways in dopaminergic neurons in vivo.

@article{Meurers2009LowDR,
  title={Low dose rotenone treatment causes selective transcriptional activation of cell death related pathways in dopaminergic neurons in vivo.},
  author={Bernhard H. Meurers and Changlian Zhu and Pierre Olivier Fernagut and Franziska Richter and Yen C. Hsia and Sheila M. Fleming and M Oh and David Elashoff and Cheryl D Dicarlo and Ronald L. Seaman and M. F. Chesselet},
  journal={Neurobiology of disease},
  year={2009},
  volume={33 2},
  pages={182-92}
}
Mitochondrial complex I inhibition has been implicated in the degeneration of midbrain dopaminergic (DA) neurons in Parkinson's disease. However, the mechanisms and pathways that determine the cellular fate of DA neurons downstream of the mitochondrial dysfunction have not been fully identified. We conducted cell-type specific gene array experiments with nigral DA neurons from rats treated with the complex I inhibitor, rotenone, at a dose that does not induce cell death. The genome wide screen… CONTINUE READING