Low-dose radiation-induced protective process and implications for risk assessment, cancer prevention, and cancer therapy.

@article{Scott2007LowdoseRP,
  title={Low-dose radiation-induced protective process and implications for risk assessment, cancer prevention, and cancer therapy.},
  author={Bobby R. Scott},
  journal={Dose-response : a publication of International Hormesis Society},
  year={2007},
  volume={5 2},
  pages={131-49}
}
A low-dose protective apoptosis-mediated (PAM) process is discussed that appears to be turned on by low-dose gamma and X rays but not by low-dose alpha radiation. PAM is a bystander effect that involves cross-talk between genomically compromised [e.g., mutants, neoplastically transformed, micronucleated] cells and nongenomically compromised cells. A novel neoplastic cell transformation model, NEOTRANS(3), is discussed that includes PAM. With NEOTRANS(3), PAM is activated by low doses and… CONTINUE READING