Low-dose probenecid selectively inhibits urinary excretion of phenolsulfonphthalein in rats without affecting biliary excretion.

@article{Shin2013LowdosePS,
  title={Low-dose probenecid selectively inhibits urinary excretion of phenolsulfonphthalein in rats without affecting biliary excretion.},
  author={Yong-Jun Shin and Joo Hyun Lee and Ju-Hee Oh and Young-Joo Lee},
  journal={Journal of applied toxicology : JAT},
  year={2013},
  volume={33 6},
  pages={511-5}
}
Renal organic anion transport systems play an important role in the excretion of anionic drugs and toxic compounds. Probenecid has been used as a potent inhibitor of urinary and biliary excretion of anionic compounds mediated by transporters such as organic anion transporters and multidrug resistance-associated protein 2 (Mrp2). The purpose of this study was to optimize the dose of probenecid required for selective inhibition of urinary excretion of anionic compounds in rats, without inhibition… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Similar Papers

Loading similar papers…