Low-dose prednisone induces rapid reversible axial bone loss in patients with rheumatoid arthritis. A randomized, controlled study.

@article{Laan1993LowdosePI,
  title={Low-dose prednisone induces rapid reversible axial bone loss in patients with rheumatoid arthritis. A randomized, controlled study.},
  author={Roland F. J. M. Laan and Peit L C M van Riel and L B van de Putte and Leon J Th O van Erning and Martin A van't Hof and J. Albert M. Lemmens},
  journal={Annals of internal medicine},
  year={1993},
  volume={119 10},
  pages={963-8}
}
OBJECTIVE To determine the effects of a short course of a low dose of a glucocorticoid agent on bone mass. DESIGN Double-blind, placebo-controlled, randomized study. SETTING Outpatient clinic of a university hospital. PATIENTS Forty patients with active rheumatoid arthritis. INTERVENTION All patients started receiving intramuscular gold salts. In addition, they were randomly allocated to receive either prednisone or placebo. The initial dose was 10 mg/d, which was tapered between weeks… CONTINUE READING
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