Low-dose photodynamic therapy increases endothelial cell proliferation and VEGF expression in nude mice brain

@article{Zhang2005LowdosePT,
  title={Low-dose photodynamic therapy increases endothelial cell proliferation and VEGF expression in nude mice brain},
  author={Xuepeng Zhang and Feng Jiang and Zheng Gang Zhang and Steven N. Kalkanis and Xin Hong and Ana C deCarvalho and Jieli Chen and Hongyan Yang and Adam M. Robin and Michael Chopp},
  journal={Lasers in Medical Science},
  year={2005},
  volume={20},
  pages={74-79}
}
We tested whether low-dose photodynamic therapy (PDT) induces an angiogenic response in the normal brain of nude mice (n=20). Normal brains of nude mice were subjected to PDT at low doses (Photofrin: 2 mg/kg; optical: 2 J/cm2 and 4 J/cm2). BrdU (50 mg/kg) was injected (intraperitoneally, i.p.) daily from PDT treatment to sacrifice (1 and 2 weeks after PDT). Laser scanning confocal microscopy, immunohistochemistry, and immunofluorescence staining were performed to assay angiogenic response… CONTINUE READING
8 Citations
19 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 19 references

Malignant astrocytomas

  • MK Nicholas, MD Prados, DA Larson
  • Loeffler J (eds) Cancer of the nervous system
  • 1997
1 Excerpt

Similar Papers

Loading similar papers…