Low-dose perinatal exposure to di(2-ethylhexyl) phthalate induces anti-androgenic effects in male rats.

@article{Christiansen2010LowdosePE,
  title={Low-dose perinatal exposure to di(2-ethylhexyl) phthalate induces anti-androgenic effects in male rats.},
  author={Sofie Christiansen and Julie Boberg and Marta Axelstad and Majken Dalgaard and Anne Marie Vinggaard and Stine Broeng Metzdorff and Ulla Hass},
  journal={Reproductive toxicology},
  year={2010},
  volume={30 2},
  pages={313-21}
}
Perinatal di(2-ethylhexyl) phthalate (DEHP) exposure was examined in time-mated Wistar rats gavaged from gestation day 7 to postnatal day 16 with doses from 3 to 900 mg/kg-d. These doses covered the whole dose-response curve for the demasculinizing effects of DEHP including low-dose effects. At a relatively low dose of 10 mg/kg-d, DEHP caused adverse anti-androgenic effects on male rat development as male anogenital distance was decreased, the incidence of nipple retention was increased, weight… CONTINUE READING