Low-dose paclitaxel modulates tumour fibrosis in gastric cancer

@inproceedings{Tsukada2013LowdosePM,
  title={Low-dose paclitaxel modulates tumour fibrosis in gastric cancer},
  author={Tomoya Tsukada and Sachio Fushida and Shinichi Harada and Shiroh Terai and Yasumichi Yagi and Jun Kinoshita and Katsunobu Oyama and Hidehiro Tajima and Itasu Ninomiya and Takaharu Fujimura and Takehiro Ohta},
  booktitle={International journal of oncology},
  year={2013}
}
Various treatments have been used for peritoneal dissemination, which is the most common mode of metastasis in gastric cancer, but sufficiently good clinical outcomes have not yet been obtained because of the presence of rich fibrous components and acquired drug resistance. Epithelial-mesenchymal transition (EMT) is one of the major causes of tissue fibrosis and transforming growth factor-β (TGF-β) has a pivotal function in the progression of EMT. Smad proteins play an important role in the TGF… CONTINUE READING

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