Low dose of propranolol down-modulates bone resorption by inhibiting inflammation and osteoclast differentiation.

@article{Rodrigues2012LowDO,
  title={Low dose of propranolol down-modulates bone resorption by inhibiting inflammation and osteoclast differentiation.},
  author={Wellington Francisco Rodrigues and Mila F M Madeira and Tarc{\'i}lia Aparecida da Silva and Juliana Trindade Clemente-Napimoga and Camila Botelho Miguel and Valdo J Dias-da-Silva and Oct{\'a}vio Barbosa-Neto and Alexandre H. Lopes and Marcelo Henrique Napimoga},
  journal={British journal of pharmacology},
  year={2012},
  volume={165 7},
  pages={2140-51}
}
BACKGROUND AND PURPOSE Bones are widely innervated, suggesting an important role for the sympathetic regulation of bone metabolism, although there are controversial studies. We investigated the effects of propranolol in a model of experimental periodontal disease. EXPERIMENTAL APPROACH Rats were assigned as follows: animals without ligature; ligated animals receiving vehicle and ligated animals receiving 0.1, 5 or 20 mg·kg(-1) propranolol. After 30 days, haemodynamic parameters were measured… CONTINUE READING