Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies

@article{Folkesson2010LowDO,
  title={Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies},
  author={Anna Folkesson and Per Hartvig Honor{\'e} and Lene Munkholm Andersen and Pernille Kristensen and Ole Jannik Bjerrum},
  journal={Journal of Neural Transmission},
  year={2010},
  volume={117},
  pages={1377-1385}
}
The use of cholinergic drugs, either alone or in combination with other drugs, has been suggested as an approach to improve treatment outcome for patients suffering from neuropathic pain. The present study was undertaken in the rat spared nerve injury model of neuropathic pain to evaluate the effect of the cholinesterase inhibitor donepezil when administered (1) alone and (2) as low-dose in combination with the first-line recommendation gabapentin. The co-administration studies were performed… CONTINUE READING
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