Low dose of arsenic trioxide triggers oxidative stress in zebrafish brain: expression of antioxidant genes.

@article{Sarkar2014LowDO,
  title={Low dose of arsenic trioxide triggers oxidative stress in zebrafish brain: expression of antioxidant genes.},
  author={Shuvasree Sarkar and Sandip Mukherjee and Ansuman Chattopadhyay and Shelley Bhattacharya},
  journal={Ecotoxicology and environmental safety},
  year={2014},
  volume={107},
  pages={1-8}
}
Occurrence of arsenic in the aquatic environment of West Bengal (India), Bangladesh and other countries are of immediate environmental concern. In the present study, zebrafish (Danio rerio) was used as a model to investigate oxidative stress related enzyme activities and expression of antioxidant genes in the brain to 50µg/L arsenic trioxide for 90 days. In treated fish, generation of reactive oxygen species (ROS), malondialdehyde (MDA) and conjugated diene (CD) showed a triphasic response… CONTINUE READING

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