Low-dose neuroleptic treatment of outpatient schizophrenics. I. Preliminary results for relapse rates.

@article{Kane1983LowdoseNT,
  title={Low-dose neuroleptic treatment of outpatient schizophrenics. I. Preliminary results for relapse rates.},
  author={John M. Kane and Arthur E Rifkin and Margaret G Woerner and George Reardon and S Sarantakos and D Schiebel and Jorge R. Ramos-Lorenzi},
  journal={Archives of general psychiatry},
  year={1983},
  volume={40 8},
  pages={893-6}
}
In an attempt to begin to establish minimum effective dosage requirements for the maintenance treatment of schizophrenia, we undertook a double-blind comparison of low-dose fluphenazine decanoate (1.25 to 5.0 mg/2 wk) with the standard-dose regimen (12.5 to 50.0 mg/2 wk) in outpatient schizophrenics. For the first 126 patients studied, cumulative relapse rates at one year for the low dose were 56% and for the standard dose 7%, a significant difference. Despite the fact that very little… CONTINUE READING

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