Low-dose methotrexate enhances cycling of highly anaplastic cancer cells

@article{Cipolleschi2017LowdoseME,
  title={Low-dose methotrexate enhances cycling of highly anaplastic cancer cells},
  author={M. G. Cipolleschi and I. Marzi and E. Rovida and M. Olivotto and P. Dello Sbarba},
  journal={Cell Cycle},
  year={2017},
  volume={16},
  pages={280 - 285}
}
  • M. G. Cipolleschi, I. Marzi, +2 authors P. Dello Sbarba
  • Published 2017
  • Biology, Medicine
  • Cell Cycle
  • ABSTRACT We previously showed that cellular RedOx state governs the G1-S transition of AH130 hepatoma, a tumor spontaneously reprogrammed to the embryonic stem cell stage. This transition is impaired when the mithocondrial electron transport system is blocked by specific inhibitors (antimycin A) or the respiratory chain is saturated by adding to the cells high concentrations of pyruvate. The antimycin A or pyruvate block is removed by the addition of adequate concentrations of folate (F). This… CONTINUE READING
    5 Citations

    References

    SHOWING 1-10 OF 28 REFERENCES
    Response of methylenetetrahydrofolate levels to methotrexate in Krebs ascites cells.
    • 14
    • PDF
    Hypoxia-resistant profile implies vulnerability of cancer stem cells to physiological agents, which suggests new therapeutic targets
    • 20
    Resistance Mechanisms to Methotrexate in Tumors
    • 68
    • PDF
    Transport of methotrexate in Chinese hamster ovary cells: a mutant defective in methotrexate uptake and cell binding.
    • 36
    The metabolically-modulated stem cell niche: a dynamic scenario regulating cancer cell phenotype and resistance to therapy
    • 35
    • PDF
    The involvement of a Nanog, Klf4 and c-Myc transcriptional circuitry in the intertwining between neoplastic progression and reprogramming
    • 27
    Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance.
    • Nitzan Gonen, Y. Assaraf
    • Biology, Medicine
    • Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
    • 2012
    • 280