Low-dose low-frequency imiglucerase as a starting regimen of enzyme replacement therapy for patients with type I Gaucher disease.

@article{Elstein1998LowdoseLI,
  title={Low-dose low-frequency imiglucerase as a starting regimen of enzyme replacement therapy for patients with type I Gaucher disease.},
  author={Deborah Elstein and Aya Abrahamov and Irith Hadas-Halpern and Ann Meyer and Ari Zimran},
  journal={QJM : monthly journal of the Association of Physicians},
  year={1998},
  volume={91 7},
  pages={483-8}
}
The issue of the interplay of optimal dosage and frequency regimens for enzyme replacement therapy in type I Gaucher disease has been a source of controversy during the 7 years since the introduction of the placenta-derived enzymatic preparation in 1991. We present the results of treatment with the human recombinant form of the enzyme in 28 type I Gaucher patients, who have been treated for 6 to 24 months. As long as cost is an important factor in the management of patients with Gaucher disease… CONTINUE READING

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