Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action

@article{Koppert2000LowdoseLR,
  title={Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action},
  author={Wolfgang Koppert and Nikola Ostermeier and Reinhard Sittl and Christian Weidner and Martin Schmelz},
  journal={Pain},
  year={2000},
  volume={85},
  pages={217-224}
}
Sodium channel blockers are approved for intravenous administration in the treatment of neuropathic pain states. Preclinical studies have suggested antihyperalgesic effects on the peripheral as well as the central nervous system. The objective of this study was to determine mechanisms of action of low-dose lidocaine in experimental induced, secondary hyperalgesia. In a first experimental trial, participants (n=12) received lidocaine systemically (a bolus injection of 2 mg/kg in 10 min followed… CONTINUE READING

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