Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats

@article{Xu2004LowDI,
  title={Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats},
  author={Lin Xu and Susan C Fagan and Jennifer L Waller and D. A. Edwards and Cesario V. Borlongan and Jianqing Zheng and William D Hill and Giora Feuerstein and David C. Hess},
  journal={BMC Neurology},
  year={2004},
  volume={4},
  pages={7 - 7}
}
BACKGROUND Minocycline, a semi-synthetic tetracycline antibiotic, is an effective neuroprotective agent in animal models of cerebral ischemia when given in high doses intraperitoneally. The aim of this study was to determine if minocycline was effective at reducing infarct size in a Temporary Middle Cerebral Artery Occlusion model (TMCAO) when given at lower intravenous (IV) doses that correspond to human clinical exposure regimens. METHODS Rats underwent 90 minutes of TMCAO. Minocycline or… CONTINUE READING
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