Low-dose intradermal and intramuscular vaccination against hepatitis B.

  title={Low-dose intradermal and intramuscular vaccination against hepatitis B.},
  author={Joe P. Bryan and Maria H. Sjogren and Peter L. Perine and Llewellyn J Legters},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  volume={14 3},
Hepatitis B and its sequelae are global problems preventable by immunization. Expense limits the use of hepatitis B vaccines, but low-dose intradermal immunization has been evaluated as a cost-saving strategy in numerous studies. With few exceptions, low-dose intradermal plasma-derived vaccines have elicited protective levels of antibody in 82%-100% of young healthy adults--a proportion similar to that noted with full-dose regimens; peak levels of antibody to hepatitis B surface antigen (HBsAg… CONTINUE READING


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