Low-dose indomethacin after ischemic acute kidney injury prevents downregulation of Oat1/3 and improves renal outcome.

@article{Schneider2009LowdoseIA,
  title={Low-dose indomethacin after ischemic acute kidney injury prevents downregulation of Oat1/3 and improves renal outcome.},
  author={Reinhard Schneider and Moritz Meusel and Sylvia Renker and Claudia C. Bauer and Hildegard Holzinger and Marc R{\"o}der and Christoph Wanner and Michael Gekle and Christoph Sauvant},
  journal={American journal of physiology. Renal physiology},
  year={2009},
  volume={297 6},
  pages={
          F1614-21
        }
}
We have previously shown that expression of renal organic anion transporters Oat1 and Oat3 is diminished by prostaglandin E(2) (PGE(2)) and that both transporters are downregulated after renal ischemia. Because PGE(2) is increased after renal ischemia and is generated by cyclooxygenases (COX), we investigated the effect of the COX inhibitor indomethacin on expression of Oat1/3 after ischemic acute kidney injury (iAKI). iAKI was induced in rats by bilateral clamping of renal arteries for 45 min… CONTINUE READING

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