Low-dose immunosuppression may unmask type I diabetes mellitus by specific inactivation of suppressor cells.

@article{Mandel1986LowdoseIM,
  title={Low-dose immunosuppression may unmask type I diabetes mellitus by specific inactivation of suppressor cells.},
  author={Tom E. Mandel and Richard. Cuthbertson},
  journal={Medical hypotheses},
  year={1986},
  volume={19 4},
  pages={325-31}
}
Type I diabetes mellitus is strongly genetically linked to the major histocompatibility complex but relatively few potentially susceptible people, who are presumably frequently exposed to appropriate triggering factors (e.g. viral illness, environmental agents), develop overt disease. It is possible that some such individuals show latent disease (e.g. islet cell antibodies and perhaps local pancreatic pathology) that does not progress. On the basis of animal data and some clinical evidence we… CONTINUE READING