Low-dose hyper-radiosensitivity: past, present, and future.

  title={Low-dose hyper-radiosensitivity: past, present, and future.},
  author={Brian Marples and Spencer J. Collis},
  journal={International journal of radiation oncology, biology, physics},
  volume={70 5},
This review article discusses the biology of low-dose hyper-radiosensitivity (HRS) with reference to the molecular regulation of DNA repair and cell cycle control processes. Particular attention is paid to the significance of G2-phase cell cycle checkpoints in overcoming low-dose hyper-radiosensitivity and the impact of HRS on low-dose rate radiobiology. The history of HRS from the original in vivo discovery to the most recent in vitro and clinical data are examined to present a unifying… CONTINUE READING
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