Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression.

@article{Coviello2005LowdoseHC,
  title={Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression.},
  author={Andrea D. Coviello and Alvin M. Matsumoto and William J. Bremner and Karen L Herbst and John K Amory and Bradley D. Anawalt and Paul R. Sutton and William W. Wright and Terry R. Brown and Xiaohua Yan and Barry R. Zirkin and Jonathan P. Jarow},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2005},
  volume={90 5},
  pages={2595-602}
}
In previous studies of testicular biopsy tissue from healthy men, intratesticular testosterone (ITT) has been shown to be much higher than serum testosterone (T), suggesting that high ITT is needed relative to serum T for normal spermatogenesis in men. However, the quantitative relationship between ITT and spermatogenesis is not known. To begin to address this issue experimentally, we determined the dose-response relationship between human chorionic gonadotropin (hCG) and ITT to ascertain the… CONTINUE READING
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