Low-dose hepatitis B immunoglobulin given "on demand" in combination with lamivudine: a highly cost-effective approach to prevent recurrent hepatitis B virus infection in the long-term follow-up after liver transplantation.

@article{Paolo2004LowdoseHB,
  title={Low-dose hepatitis B immunoglobulin given "on demand" in combination with lamivudine: a highly cost-effective approach to prevent recurrent hepatitis B virus infection in the long-term follow-up after liver transplantation.},
  author={Daniele di Paolo and Giuseppe Tisone and P. Del Piccolo and Ilaria Lenci and Settimio Zazza and Mario Angelico},
  journal={Transplantation},
  year={2004},
  volume={77 8},
  pages={1203-8}
}
BACKGROUND Cost of long-term prophylaxis with high-dose human hepatitis B immune globulin (HBIg) after liver transplantation is extremely high. The aim of the present study was to assess consumption rates of high (5,000 IU) and low (2,000 IU) doses of HBIg given intravenously "on demand", and determine their cost-effectiveness compared with conventional fixed monthly schedules. METHODS The study included 11 male patients (mean age 53 years) who received transplants for hepatitis B virus (HBV… CONTINUE READING

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Posttransplantation prophylaxis with primary high-dose hepatitis B immunoglobulin monotherapy and complementary preemptive antiviral add-on.

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