Low-dose gemcitabine depletes regulatory T cells and improves survival in the orthotopic Panc02 model of pancreatic cancer.

@article{Shevchenko2013LowdoseGD,
  title={Low-dose gemcitabine depletes regulatory T cells and improves survival in the orthotopic Panc02 model of pancreatic cancer.},
  author={Ivan Shevchenko and Svetlana Karakhanova and Sabine Soltek and Julia Link and Jagadeesh Bayry and Jens Werner and Viktor Umansky and Alexandr V Bazhin},
  journal={International journal of cancer},
  year={2013},
  volume={133 1},
  pages={98-107}
}
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human neoplasms with extremely poor prognosis and a low survival rate. Immunosuppressive cell populations, e.g. regulatory T cells (Treg), appear to be important in PDAC, contributing to patient's poor prognosis. Therefore, we investigated the PDAC microenvironment with a focus on conventional and regulatory T cells in view of their potential therapeutic importance. We found that tumors from the murine Panc02 orthotopic model… CONTINUE READING
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