Low-dose gamma-ray irradiation induces translocation of Nrf2 into nuclear in mouse macrophage RAW264.7 cells.

@article{Tsukimoto2010LowdoseGI,
  title={Low-dose gamma-ray irradiation induces translocation of Nrf2 into nuclear in mouse macrophage RAW264.7 cells.},
  author={Mitsutoshi Tsukimoto and Nana Tamaishi and Takujiro Homma and Shuji Kojima},
  journal={Journal of radiation research},
  year={2010},
  volume={51 3},
  pages={349-53}
}
The transcription factor nuclear erythroid-derived 2-related factor 2 (Nrf2) regulates expression of genes encoding antioxidant proteins involved in cellular redox homeostasis, while gamma-ray irradiation is known to induce reactive oxygen species in vivo. Although activation of Nrf2 by various stresses has been studied, it has not yet been determined whether ionizing irradiation induces activation of Nrf2. Therefore, we investigated activation of Nrf2 in response to gamma-irradiation in mouse… CONTINUE READING

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