Low-dose gamma-irradiation promotes survival of injured neurons in the central nervous system via homeostasis-driven proliferation of T cells.

@article{Kipnis2004LowdoseGP,
  title={Low-dose gamma-irradiation promotes survival of injured neurons in the central nervous system via homeostasis-driven proliferation of T cells.},
  author={Jonathan Kipnis and H. I. Avidan and Yifat Markovich and Tal Mizrahi and Ehud Hauben and Tatyana B. Prigozhina and Shimon Slavin and Michal Schwartz},
  journal={The European journal of neuroscience},
  year={2004},
  volume={19 5},
  pages={1191-8}
}
Protective autoimmunity was only recently recognized as a mechanism for attenuating the progression of neurodegeneration. Using a rat model of optic nerve crush or contusive spinal cord injury, and a mouse model of neurodegenerative conditions caused by injection of a toxic dose of intraocular glutamate, we show that a single low dose of whole-body or lymphoid-organ gamma-irradiation significantly improved the spontaneous recovery. Animals with severe immune deficiency or deprived of mature T… CONTINUE READING
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