Low dose fibroblast growth factor-2 (FGF-2) enhances bone morphogenetic protein-2 (BMP-2)-induced ectopic bone formation in mice.

@article{Nakamura2005LowDF,
  title={Low dose fibroblast growth factor-2 (FGF-2) enhances bone morphogenetic protein-2 (BMP-2)-induced ectopic bone formation in mice.},
  author={Yukio Nakamura and Keiji Tensho and Hiroyuki Nakaya and Masashi Nawata and Takahiro Okabe and Shigeyuki Wakitani},
  journal={Bone},
  year={2005},
  volume={36 3},
  pages={399-407}
}
To examine how fibroblast growth factor-2 (FGF-2) affects the BMP signaling pathway during bone morphogenetic protein-2 (BMP-2)-induced ectopic bone formation, we implanted type I collagen disks containing constant amounts of BMP-2 (5 micrograms) and varying amounts of FGF-2 onto the back muscles of adult male mice. We then performed histological analyses and histomorphometry, and measured bone mineral density and radiopaque area on the discs 1, 2, and 3 weeks after implantation. We also… CONTINUE READING

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