Low-dose estradiol spray to treat vasomotor symptoms: a randomized controlled trial.

@article{Buster2008LowdoseES,
  title={Low-dose estradiol spray to treat vasomotor symptoms: a randomized controlled trial.},
  author={John E. Buster and William D. Koltun and Maria Luz G Pascual and Wesley W. Day and Craig Peterson},
  journal={Obstetrics and gynecology},
  year={2008},
  volume={111 6},
  pages={1343-51}
}
OBJECTIVE To investigate the safety and efficacy of a transdermal estradiol (E2) spray in women with postmenopausal vasomotor symptoms. METHOD A randomized, double-blind, placebo-controlled, multicenter, parallel-group clinical trial was conducted. Postmenopausal women (N=454) with at least eight moderate-to-severe hot flushes per day applied daily, one, two, or three E2 (90 microliter spray contains 1.53 mg E2) or matching placebo sprays. The primary efficacy endpoints were mean change from… CONTINUE READING

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Evamist (estradiol transdermal spray) product label approved by the U.S

  • Vivus, Inc
  • Food and Drug Administration. Available at: http…
  • 2008

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