Low dose erythropoietin stimulates bone healing in mice.

  title={Low dose erythropoietin stimulates bone healing in mice.},
  author={Patric Garcia and V Speidel and Claudia Scheuer and Matthias W Laschke and J{\"o}rg Holstein and T. Scheuer Histing and Tim Pohlemann and Michael Dieter Menger},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  volume={29 2},
Beyond its classical role in regulation of erythropoiesis, erythropoietin (EPO) has been shown to exert protective and regenerative actions in a variety of non-hematopoietic tissues. However, little is known about potential actions in bone regeneration. To analyze fracture healing in mice, a femoral 0.25 mm osteotomy gap was stabilized with a pin-clip technique. Animals were treated with 500 U EPO/kg bw per day or with vehicle only. After 2 and 5 weeks, fracture healing was analyzed… CONTINUE READING


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