Low-dose endotoxin potentiates capsaicin-induced pain in man: evidence for a pain neuroimmune connection.

@article{Hutchinson2013LowdoseEP,
  title={Low-dose endotoxin potentiates capsaicin-induced pain in man: evidence for a pain neuroimmune connection.},
  author={Mark R Hutchinson and Mara Buijs and Jonathan Tuke and Yuen Hei Kwok and Melanie G. Gentgall and Desmond B. Williams and Paul Edward Rolan},
  journal={Brain, behavior, and immunity},
  year={2013},
  volume={30},
  pages={3-11}
}
Despite the wealth of evidence in animals that immune activation has a key role in the development and maintenance of chronic pain, evidence to support this in humans is scant. We have sought such evidence by examining the effect of a subtle immunological stimulus, low dose intravenous endotoxin, on the allodynia, hyperalgesia, flare and pain produced by intradermal capsaicin in healthy volunteers. Here we provide evidence of immune priming of this neuropathic-like pain response in humans… CONTINUE READING

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