Low-dose endotoxin inhalation in healthy volunteers - a challenge model for early clinical drug development

Abstract

BACKGROUND Inhalation of endotoxin (LPS) induces a predominantly neutrophilic airway inflammation and has been used as model to test the anti-inflammatory activity of novel drugs. In the past, a dose exceeding 15-50 μg was generally needed to induce a sufficient inflammatory response. For human studies, regulatory authorities in some countries now request… (More)
DOI: 10.1186/1471-2466-13-19

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Cite this paper

@inproceedings{Janssen2013LowdoseEI, title={Low-dose endotoxin inhalation in healthy volunteers - a challenge model for early clinical drug development}, author={O T A Janssen and Frank Schaumann and Olaf Holz and Bianca Lavae-Mokhtari and Lutz Welker and Carla Winkler and Heike Biller and Norbert Krug and J M Hohlfeld}, booktitle={BMC pulmonary medicine}, year={2013} }