Low-dose effects and biphasic effect profiles: is trenbolone a genotoxicant?

  title={Low-dose effects and biphasic effect profiles: is trenbolone a genotoxicant?},
  author={Melanie Boettcher and Thomas Kosmehl and Thomas Braunbeck},
  journal={Mutation research},
  volume={723 2},
Over the last years, extensive research has documented endocrine-disrupting activities for a significant number of substances including, among others, hormones, pharmaceuticals, pesticides and surfactants. Nonetheless, for most endocrine disruptors, toxicological profiles are still incomplete or even lacking. A systematic review has shown that a number of endocrine disruptors with steroid-modulating effects may also exert mutagenic and carcinogenic activities. For trenbolone, an androgenic… CONTINUE READING


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A novel contact assay for testing genotoxicity of chemicals and whole sediments in zebrafish embryos

  • A. V. Hallare T. Kosmehl, G. Reifferscheid, W. Manz, T. Braunbeck, H. Hollert
  • Comp . Biochem . Phys .
  • 2009

Gutzeit , 17 aEthinylestradiol affects reproduction , sexual differentiation and aromatase gene expression of the medaka ( Oryzias latipes )

  • O. H.
  • Aquat . Toxicol .
  • 2009

Molecular mechanisms of micronucleus , nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

  • M. Kirsch-Volders, A. T. Natarajan, +6 authors P. Thomas
  • The Comet Assay in Toxicology ( Issues in…
  • 2009

Effects of endocrinedisrupting chemicals on the expression of CYP 19 genes in zebrafish ( Danio rerio ) juveniles

  • A. R. Place Y. Kazeto, J. M. Trant
  • Aquat . Toxicol .
  • 2006

Structural and functional diversity of microbial communities from a lake sediment contaminated with trenbolone , an endocrinedisrupting chemical

  • K. Pritsch V. Radl, J. C. Munch, M. Schloter
  • Environ . Pollut .
  • 2005

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