Low-dose doxorubicin with carotenoids selectively alters redox status and upregulates oxidative stress-mediated apoptosis in breast cancer cells.

@article{Vijay2018LowdoseDW,
  title={Low-dose doxorubicin with carotenoids selectively alters redox status and upregulates oxidative stress-mediated apoptosis in breast cancer cells.},
  author={Kariyappa Vijay and Poorigali Raghavendra-Rao Sowmya and Bangalore Prabhashankar Arathi and Shivaprasad Shilpa and Hulikere Jagdish Shwetha and Marisiddaiah Raju and Vallikannan Baskaran and Rangaswamy Lakshminarayana},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2018},
  volume={118},
  pages={
          675-690
        }
}
  • Kariyappa VijayP. Sowmya R. Lakshminarayana
  • Published 1 August 2018
  • Biology, Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Pro-oxidant Actions of Carotenoids in Triggering Apoptosis of Cancer Cells: A Review of Emerging Evidence

This review discusses possible mechanisms of carotenoid-triggered ROS production in cancer cells, the activation of pro-apoptotic signaling by ROS, and apoptotic cell death, and synergistic actions ofcarotenoids with ROS-inducing anti-cancer drugs are discussed, and research gaps are suggested.

Epigenetic immunomodulatory effect of eugenol and astaxanthin on doxorubicin cytotoxicity in hormonal positive breast Cancer cells

Eugenol and AST potentiated the anticancer activity of DOX through epigenetic histones acetylation along with the immunonomodulation of different apoptotic approaches in MCF7 cells.

Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back

The article considers the utility of carotenoids in the framework of 3P medicine by using nanotechnological approaches, solid dispersions, microemulsions or biofortification that significantly increase the anti-cancer and pro-apoptotic efficacy of carOTenoids.

Chemopreventive Effect of β-Cryptoxanthin on Human Cervical Carcinoma (HeLa) Cells Is Modulated through Oxidative Stress-Induced Apoptosis

TUNEL assay carried out to detect nuclei DNA damage showed 52% TUNEL-positive cells after treatment with a physiological concentration of β-cryptoxanthin (1.0 μM), which validates its potential as an anticancer drug of natural origin.

An update on the mechanisms related to cell death and toxicity of doxorubicin and the protective role of nutrients.

  • A. Varela-LópezM. Battino J. Quiles
  • Biology, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2019

Fucoxanthin Holds Potential to Become a Drug Adjuvant in Breast Cancer Treatment: Evidence from 2D and 3D Cell Cultures

Fx has potential to become an adjuvant for Dox chemotherapy regimens in BC treatment, and the combination of Fx and Dox showed higher cytotoxic effects on 3D cultures compared to the isolated compounds.

Cytotoxic mechanisms of doxorubicin at clinically relevant concentrations in breast cancer cells

Insight is provided into the mechanistic pathway(s) of DOX at levels found within patients and establishes the magnitude of effect for each mechanism, as well as updating the concentration and time-dependent trends ofDOX mechanisms at representative clinical concentrations.

Therapeutic Role of Carotenoids in Blood Cancer: Mechanistic Insights and Therapeutic Potential

The therapeutic potential of carotenoids in blood cancers is focused on, addressing various mechanisms and signaling pathways that mediate their therapeutic efficacy.

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    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
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Chemopreventive Effect of β-Cryptoxanthin on Human Cervical Carcinoma (HeLa) Cells Is Modulated through Oxidative Stress-Induced Apoptosis

TUNEL assay carried out to detect nuclei DNA damage showed 52% TUNEL-positive cells after treatment with a physiological concentration of β-cryptoxanthin (1.0 μM), which validates its potential as an anticancer drug of natural origin.

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A newly discovered mechanistic difference in DOX-induced apoptotic cell death in normal versus tumor cells will be useful in developing drugs that selectively mitigate the toxic side effects of DOX without affecting its antitumor action.
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