Low dose discontinued FK506 treatment enhances peripheral nerve regeneration.

@article{Chunasuwankul2002LowDD,
  title={Low dose discontinued FK506 treatment enhances peripheral nerve regeneration.},
  author={Raywat Chunasuwankul and Chantal Ayrout and Zeynep Dereli and Andras Gal and Marco Lanzetta and Earl Owen},
  journal={International surgery},
  year={2002},
  volume={87 4},
  pages={
          274-8
        }
}
FK506 has been reported to enhance nerve regeneration in various rodent models. However, both the immunosuppressive properties and potential side effects may preclude the broad clinical use of FK506 to speed nerve regeneration. In this study, we examined the nerve regenerative property of a low, nonimmunosuppressive dose (0.5 mg/kg/day) of FK506. Two treatment schedules (continuous versus discontinuous) were compared. Evaluations were perforrmed at 1, 2, and 3 months. The gastrocnemius muscle… CONTINUE READING

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