Low-dose diazepam primes motivation for alcohol and alcohol-related semantic networks in problem drinkers

  title={Low-dose diazepam primes motivation for alcohol and alcohol-related semantic networks in problem drinkers},
  author={Constantine X. Poulos and Martin Zack},
  journal={Behavioural Pharmacology},
Considerable research with animals indicates that the GABA–benzodiazepine (BZ) system plays a key role in alcohol reinforcement. However, only limited research appears to have assessed this issue directly in humans. The present study investigated whether low-dose diazepam would cross-prime motivation for alcohol in problem drinkers. Twelve male problem drinkers (Alcohol Dependence Scale; ADS score ≥9) received oral diazepam (5 mg) and placebo, in a counterbalanced manner on separate sessions… 
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