Low-dose cyclosporine and mycophenolate mofetil in renal allograft recipients with suboptimal renal function.

@article{Hueso1998LowdoseCA,
  title={Low-dose cyclosporine and mycophenolate mofetil in renal allograft recipients with suboptimal renal function.},
  author={Miguel Hueso and Jordi Bover and Daniel Ser{\'o}n and Salvador Gil-Vernet and Isabel Sabat{\'e} and Xavier Fulladosa and Rosa Isela Ramos and Oriol Coll and J. Alsina and Josep Mar{\'i}a Grinyo},
  journal={Transplantation},
  year={1998},
  volume={66 12},
  pages={1727-31}
}
BACKGROUND Cyclosporine (CsA) nephrotoxicity can be identified by functional changes and chronic renal damage. CsA-associated renal fibrosis has been related to the overproduction of transforming growth factor (TGF)-beta1, a fibrogenic cytokine. Mycophenolate mofetil (MMF) may allow CsA dose reduction without increasing the risk of rejection. METHODS We studied the impact of CsA dose reduction in association with MMF on renal function and TGF-beta1, production in 16 long-term renal allograft… CONTINUE READING