Low-dose cyclosporin A induces relapsing remitting experimental allergic encephalomyelitis in the Lewis rat

@article{Polman1988LowdoseCA,
  title={Low-dose cyclosporin A induces relapsing remitting experimental allergic encephalomyelitis in the Lewis rat},
  author={C. H. Polman and Irina Matthaei and Cornelis Jan de Groot and J. C. Koetsier and Christine D. Dijkstra},
  journal={Journal of Neuroimmunology},
  year={1988},
  volume={17},
  pages={209-216}
}
Experimental allergic encephalomyelitis (EAE) in Lewis rats is an acute monophasic autoimmune disease. It can be treated prophylactically and therapeutically with high doses of cyclosporin A (CsA). Here we demonstrate that low-dose CsA does not prevent a first attack of EAE, but, on the contrary, induces a chronic relapsing form of the disease in 100% of Lewis rats examined. Possible explanations for the high relapse rate after low-dose CsA treatment are discussed. Further studies will be… CONTINUE READING

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