Low-dose continuous infusion cisplatin combined with external beam irradiation for advanced colorectal adenocarcinoma and unresectable non-small cell lung carcinoma.

@article{Ellerbroek1991LowdoseCI,
  title={Low-dose continuous infusion cisplatin combined with external beam irradiation for advanced colorectal adenocarcinoma and unresectable non-small cell lung carcinoma.},
  author={Nancy A Ellerbroek and Frank V. Fossella and Tyvin A. Rich and Jaffer A. Ajani and Ritsuko Komaki and J. L. A. Roth and Paul Y. Holoye},
  journal={International journal of radiation oncology, biology, physics},
  year={1991},
  volume={20 2},
  pages={351-5}
}
In a dose escalation study, CIS-diamminedichloroplatinum II (cisplatin) was combined with a standard dose of external beam irradiation in 15 patients with localized non-small cell lung cancer (NSCLC) and 16 patients with fixed or recurrent localized adenocarcinoma of the rectum. Cisplatin was given 5 days a week during irradiation using an outpatient portable infusion pump system, at doses of 3.2 mg/m2/24 hr in 15 patients, 4.0 mg/m2/24 hr in 13 patients, and 5.0 mg/m2 24 hr in 3 patients… CONTINUE READING