Low dose combination of morphine and delta9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors.

@article{Smith2007LowDC,
  title={Low dose combination of morphine and delta9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors.},
  author={Paul A. Smith and D. E. Selley and L. J. Sim-Selley and Sandra P. Welch},
  journal={European journal of pharmacology},
  year={2007},
  volume={571 2-3},
  pages={129-37}
}
Morphine and delta9-tetrahydrocannabinol (THC) produce antinociception via mu opioid and cannabinoid CB1 receptors, respectively, located in central nervous system (CNS) regions including periaqueductal gray and spinal cord. Chronic treatment with morphine or THC produces antinociceptive tolerance and cellular adaptations that include receptor desensitization. Previous studies have shown that administration of combined sub-analgesic doses of THC+morphine produced antinociception in the absence… CONTINUE READING
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Regional differences in adaptation of CNS mu opioid receptors to chronic opioid agonist administration

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