Low-dose combination of alendronate and atorvastatin reduces ligature-induced alveolar bone loss in rats.

@article{Goes2014LowdoseCO,
  title={Low-dose combination of alendronate and atorvastatin reduces ligature-induced alveolar bone loss in rats.},
  author={Paula Goes and Iracema Matos de Melo and Luana Maria Castelo Melo Silva and Norma Maria Barros Benev{\'i}des and Nylane Maria Nunes de Alencar and Ronaldo de Albuquerque Ribeiro and Vilma Lima},
  journal={Journal of periodontal research},
  year={2014},
  volume={49 1},
  pages={45-54}
}
BACKGROUND AND OBJECTIVE Atorvastatin (ATV) has bone anabolic properties, and alendronate (ALD) is an important antiresorptive drug. This study aimed to evaluate the effects of the combination of ALD and ATV on ligature-induced alveolar bone loss in rats. MATERIAL AND METHODS Periodontitis was induced by ligature in 78 Wistar rats. Groups of six rats prophylactically received 0.9% saline (SAL), ALD (0.01 or 0.25 mg/kg subcutaneously) or ATV (0.3 or 27 mg/kg by gavage). Then, groups of six… CONTINUE READING