Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study.

@article{Hau2007LowdoseCI,
  title={Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study.},
  author={Peter Hau and Leoni A. Kunz-Schughart and Ulrich Bogdahn and Urszula Baumgart and Birgit Hirschmann and Elke Weimann and Hannes Muhleisen and Petra R{\"u}mmele and Andreas Steinbrecher and Albrecht Reichle},
  journal={Oncology},
  year={2007},
  volume={73 1-2},
  pages={
          21-5
        }
}
OBJECTIVES Combined treatment approaches targeting tumor as well as other cells contributing to tumor progression may control chemorefractory malignancies. METHODS A phase II trial was initiated to analyze the activity of continuously administered pioglitazone and rofecoxib combined with low-dose chemotherapy (capecitabine or temozolomide) in patients with high-grade gliomas (glioblastoma or anaplastic glioma). RESULTS Fourteen patients were evaluable for response and toxicity. Major side… CONTINUE READING
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